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Updated: Feb 20, 2026

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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USP7小分子阻害剤は,ユビキチン結合を妨害する

Lorna Kategaya1,2, Paola Di Lello3, Lionel Rougé3

  • 1Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.

Nature
|October 19, 2017
PubMed
まとめ

研究者は,その触媒部位からUSP7を標的とする選択的ユビキチン特異プロテアゼ-7 (USP7) 阻害剤であるGNE-6640とGNE-6776を開発した. これらの阻害剤は,細胞死を誘発し,薬剤の細胞毒性を強化することによって,がん治療に希望を示しています.

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