血管内大動脈修復を行うオペレータの放射線誘発DNA損傷
Tamer El-Sayed1, Ashish S Patel1, Jun S Cho1
1Academic Department of Vascular Surgery, School of Cardiovascular Medicine and Sciences, King's College London, BHF Centre of Excellence at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Circulation
|October 22, 2017
まとめ
EVARの放射線被曝は 操作者のDNAダメージマーカーを高めます 足のシールドは,この反応を大幅に減らし,血管内大動脈修復の手続きにおける放射線に対する保護効果を強調します.
科学分野:
- 医学放射線物理学
- 分子生物学
- 心血管外科
背景:
- 血管内大動脈修復 (EVAR) のような光学誘導介入 (FGI) は,操作者に放射線被曝のリスクをもたらします.
- 操作者のDNA損傷と修復マーカーの評価は,これらのリスクを理解し,軽減するために不可欠です.
研究 の 目的:
- EVARの手続き中にDNA損傷/修復マーカー (γ-H2AXとpATM) を測定する.
- 操業者の放射線によるDNA損傷を減らすために,脚の鉛シールドの有効性を評価する.
主な方法:
- 術後期にフローサイトメトリーを用いて,オペレータからの循環リンパ球をγ- H2AXおよびpATM発現のために分析した.
- マーカーは,脚の鉛シールド付きと無付で測定され,操作者の血液は,放射線感受性を評価するためにインビトロで照射された.
主要な成果:
- 枝分かれ/ 窓状のEVARは,処置直後に γ- H2AXとpATMのレベルを有意に増加させた (P<0. 0003).
- インフラレナルEVARでは,pATM (P<0. 04) のみ有意な増加を示した.
- 足のシールドは,枝分かれ/窓状のEVARで γ- H2AXとpATM応答を無効化し,マーカーは24時間以内にベースラインに戻った.
結論:
- この研究は,フルoroscopic大動脈の手続き中に急性DNA損傷応答を実証する最初のものです.
- 足のシールドは,複雑なEVARの間に放射線によるDNA損傷から操作者を効果的に保護します.
- このDNA損傷反応と長期の癌のリスクを関連付け,安全な放射線被曝限界を確立するためにさらなる研究が必要である.
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