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Updated: Feb 20, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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ヒトの癌における超変異の総合的な分析

Brittany B Campbell1, Nicholas Light2, David Fabrizio3

  • 1Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Cell
|October 24, 2017
PubMed
まとめ

この研究では 8万1,000以上の腫瘍を分析し ハイパーミューテーションの新たな原因を明らかにし 患者の異なるサブグループを特定しました 発見は癌の進化の理解を深め,臨床応用に役立つ.

キーワード:
DNA 修復DNA複製ガンゲノミクス癌に罹患する傾向ハイパーミューテーション免疫チェックポイント阻害剤不一致を修復するミューターター

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