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Updated: Feb 20, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

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関連分析により,65の新たな乳がんリスクロシウムが特定された

Kyriaki Michailidou1,2, Sara Lindström3,4, Joe Dennis1

  • 1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Nature
|October 24, 2017
PubMed
まとめ

この研究は,大規模な全ゲノム関連研究を通じて,乳がんリスクに関連した65の新しい遺伝的位置を特定しました. これらの発見は 遺伝的易感性に関する理解を深め パーソナライズされた予防戦略を 開発するのに役立ちます

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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA108:53

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