ピルス収縮の阻害は,細菌の表面感知を刺激する

Courtney K Ellison¹, Jingbo Kan^2,3, Rebecca S Dillard⁴

¹Department of Biology, Indiana University, 1001 East 3rd Street, Bloomington, IN 47405, USA.

Science (New York, N.Y.)

|October 28, 2017

まとめ

細菌は毛状の付属体であるピリを使って表面を感知しますピリが表面に抵抗すると粘着剤の合成が始まります

科学分野:

微生物学
細胞生物学
バクテリア粘着

背景:

バクテリアは適応しコミュニティを形成するために表面を感知する必要があります
微生物のピルは表面相互作用に関与することが知られているが,検出メカニズムは不明である.

研究の目的:

細菌が表面感知を媒介するメカニズムを解明する.
表面に関連したライフスタイルへの移行をどのように促進するか理解する.

主な方法:

顕微鏡を用いて*Caulobacter crescentus*のピリダイナミクスを視覚化する.
表面接触時にピルスの伸縮と収縮サイクルを分析する.
実験的にピルスの抵抗を誘導し,ホールドファスト合成を評価する.

主要な成果:

ピルスの伸縮と収縮のサイクルは,表面に接触するとすぐに停止します.
ピルス・サイクルの停止は,粘着剤の合成と一致する.
物理的にピルスの収縮を阻害することは,表面接触なくとも,ホールドファスト合成を誘導するのに十分です.

結論:

細菌は表面を感知し抵抗を感知します
この機械的感知メカニズムは下流の生理学的変化を誘発します例えばホールドファスト合成です
細菌が表面に付着し,生活習慣に適応するために,ピルス媒介によるメカニカルフィードバックは極めて重要です.

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