Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Sulfur Assimilation01:20

Sulfur Assimilation

393
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
393
Vitamins01:30

Vitamins

2.6K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.6K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

932
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
932
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.7K
Overview of Nitrogen Metabolism01:20

Overview of Nitrogen Metabolism

11.7K
Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of  ammonia, ammonium ions, nitrate, nitrite, or  nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
11.7K
Overview of Metabolism01:40

Overview of Metabolism

39.2K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
39.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

BRG1-mediated suppression of ferroptosis underlies BTK inhibitor resistance.

Nature communications·2026
Same author

Author Correction: Regulation of urea cycle by reversible high-stoichiometry lysine succinylation.

Nature metabolism·2026
Same author

Exercise suppresses breast cancer and reprograms the immune tumor microenvironment, cancer cell intrinsic features, and their interaction.

Journal of sport and health science·2026
Same author

Advances and resistance adaptation in BTK-targeted therapy for B-cell malignancies.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2026
Same author

Leveraging BRG1 Driven Ferroptosis Resistance to Overcome Treatment Resistance.

bioRxiv : the preprint server for biology·2025
Same author

Flux measurements of the tricarboxylic acid cycle in the tumors of mice.

Life metabolism·2025

関連する実験動画

Updated: Feb 19, 2026

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
09:28

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

13.6K

ビタミンB12の代謝に欠けているリンク

Michael A Reid1, Jihye Paik2, Jason W Locasale1

  • 1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

Cell
|November 4, 2017
PubMed
まとめ
この要約は機械生成です。

CLYBL遺伝子変異を持つ人の約3%はビタミンB12のレベルが低い. この研究は,CLYBL

さらに関連する動画

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

809
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.8K

関連する実験動画

Last Updated: Feb 19, 2026

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
09:28

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

13.6K
Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

809
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.8K

科学分野:

  • 生物化学
  • 人間 の 遺伝子
  • メタボロミクス

背景:

  • CLYBL遺伝子の変異は 人口の3%に影響します
  • これらの変種を持つ個人は,ビタミンB12のレベルが低下しています.
  • CLYBLの代謝機能はほとんど不明である.

研究 の 目的:

  • CLYBL遺伝子の代謝的役割を明らかにする.
  • CLYBL,ビタミンB12代謝,イタコナート産生との関連を調査する.
  • CLYBLの機能喪失の生理学的結果を 理解するために

主な方法:

  • CLYBLの変種を持つ個体の遺伝分析
  • メタボロミックプロフィール ダウンストリーム効果を特定する
  • CLYBL酵素の活性に関する生化学的測定

主要な成果:

  • CLYBLは代謝経路における重要な酵素として特定されています.
  • CLYBLの機能喪失型は,ビタミンB12の代謝を阻害する.
  • CLYBLの活動は,免疫調節代謝物イタコナートのレベルに影響します.

結論:

  • CLYBLはビタミンB12のホメオスタシスに重要な役割を果たします.
  • この研究は,CLYBL,ビタミンB12,イタコナートとの間の新しいリンクを確立しています.
  • CLYBLの機能を理解することは,人間の健康と代謝障害に影響を及ぼします.