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触媒RNAにおける核塩基と二重金属イオンの内球調整

Xin Liu1, Yu Chen1, Carol A Fierke1

  • 1Departments of Chemistry and ‡Biological Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|November 9, 2017
PubMed
まとめ

この研究では,リボヌクレアゼPの特定のRNA塩基が,メタルイオンと触媒としてどのように相互作用するかを明らかにした. 改変されたRNAは活性が低下し,メタルの救出実験では主要な尿素基による直接的な調整が確認された.

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