神経活動の高密度記録のための完全に統合されたシリコンプローブ
James J Jun1, Nicholas A Steinmetz2,3,4, Joshua H Siegle5
1HHMI Janelia Research Campus, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
Nature
|November 10, 2017
まとめ
研究者たちはニューラル記録のための 新しいシリコン探査機である ニューロピクセルを開発しました この技術は 自由に動いている動物の複数の脳領域に何百もの神経細胞を 同時に記録し 神経科学の研究を進めます
科学分野:
- 神経科学
- バイオエンジニアリング
- 電気生理学
背景:
- 複雑な脳機能には 広範囲にわたる神経集団の 協調的な活動が必要です
- 現在のニューラル記録技術は 空間時間的な解像度,カバー,または自由に動く対象との互換性において制限があります.
- 細胞外探査や光学画像のような既存の方法は 同時に高解像度と大規模のカバーを提供できません
研究 の 目的:
- 既存の方法の限界を克服する 新しい神経探知技術を開発する
- 高解像度の神経記録を 制御不能の動物で 大量の脳で達成する
- 複数の脳領域から何百ものニューロンを 同時に記録できるように
主な方法:
- 384の記録チャネルと960のTiNサイトを持つニューロピクセルシリコンプローブの設計と製造.
- デジタルデータ伝送のための補完的な金属酸化物半導体 (CMOS) 互換性のあるオンチップ処理の統合.
- ネズミやネズミに探査機を埋め込み,行動中の神経活動を記録する.
主要な成果:
- ニューロピクセル探査機は 探査機ごとに何百ものニューロンから 孤立したスパイク活動を記録しました
- 覚醒したマウスの 5つの脳構造から 700以上の単一のニューロンを 2つの探査機を使って同時に記録しました
- 自由に動き回る動物の複数の脳構造から記録する能力を示した.
結論:
- ニューロピクセル探査機は ニューラル記録における 画期的な進歩をもたらし 高い時空解像度と 大規模なカバーを組み合わせています
- この技術は,行動する動物の脳領域における 神経集団のダイナミクスの研究を容易にする.
- ニューロピクセルは 複雑な行動中の脳全体の ニューラル活動の記録に 新たな道を開きます
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