アメリカ大陸におけるVibrio choleraeの総合的な見方
Daryl Domman1, Marie-Laure Quilici2, Matthew J Dorman3
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. dd6@sanger.ac.uk nrt@sanger.ac.uk.
まとめ
アメリカ大陸でのコレラ流行は,世界規模でVibrio choleraeが導入された結果でした. 局所的な細菌系は 異なる病気を引き起こし 制御戦略の重要性を強調しています
科学分野:
- 微生物学
- ゲノミクス
- 流行病学
背景:
- ラテンアメリカでは1991年と2010年に 大規模なコレラ流行が起こりました
- 世界的なパンデミックであるVibrio cholerae菌株と地域住民の相互作用は不明である.
研究 の 目的:
- アメリカ大陸のコロラ菌株を 遺伝学的に特徴づけるために
- パンデミックとローカルなビブリオ・コレラの起源と関係を解明する.
主な方法:
- ビブリオ・コレラ菌の全ゲノム配列解析
- アメリカ大陸のバクテリア集団を 40年にわたって分析したものです
主要な成果:
- 2つの主要な流行は,第7のパンデミックであるエル・トル・ビブリオ・コレラの大陸間感染によって引き起こされた.
- アメリカ大陸の少なくとも7つの異なる地域系は 流行病学的に異なるコレラ症例と関連しています
- ゲノムデータは 伝染病の伝染を裏付けています
結論:
- アメリカ大陸でのパンデミックコレラは 輸入されたVibrio cholerae菌株によって引き起こされています
- 地元のVibrio choleraeの系統は,地域のコレラ流行病学において重要な役割を果たしています.
- 効果的なコレラ対策には グローバルとローカルの両方の 株を理解することが不可欠です
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