化学的に異質な表面で水によって媒介される非添加的相互作用:ノンイオン極性群と水害性相互作用
Chenxuan Wang1,2, Chi-Kuen Derek Ma1, Hongseung Yeon1
1Department of Chemical and Biological Engineering, University of Wisconsin-Madison , 1415 Engineering Drive, Madison, Wisconsin 53706, United States.
Journal of the American Chemical Society
|November 14, 2017
まとめ
プライマリアミド群はプライマリアミン群と比較して,水害性相互作用を著しく弱める. この研究は,βペプチドにおけるこれらの効果を定量化し,バイオマテリアルの設計に影響を与えています.
科学分野:
- 生物化学
- 材料科学
- 化学物理学
背景:
- 機能的な生体材料の設計には,水害性相互作用に対する極性群の影響を理解することが重要です.
- 全球アンフィフィリック (GA) βペプチドは,これらの効果を研究するための調整可能なプラットフォームを提供します.
研究 の 目的:
- GA β-ペプチドにおける隣接する非極域の水性相互作用に,原始アミンおよび原始アミド群がどのように影響するかを調査する.
- β3-ホモリシン (K) と β3-ホモグルタミン (Q) 残留物によって媒介される水害相互作用の違いを定量化する.
主な方法:
- 非極性および極性サイドチェーンを制御した安定したGAβペプチド配列の設計と合成.
- 水溶液とメタノール溶液における原子力顕微鏡 (AFM) による化学力測定
- 末端のアミンまたはアミド群との相互作用を検知するために,固体サポートされた混合モノレイヤのAFM研究.
主要な成果:
- 主なアミド群 (Q側鎖) が主なアミン群 (K側鎖) を置き換えたとき,水害性粘着相互作用は著しく弱かった.
- GA- KKKはpH10. 5で0. 61±0. 04nN,GA- QKKは0. 54±0. 01nN,GA- QQKは0±0. 01nNの相互作用を示した.
- 同様の傾向は混合モノレイヤでのAFM研究でも観察され,極性群の同一性の影響を確認した.
結論:
- 隣接する非イオン極性群,特にプライマリアミンとアミドは,隣接する水害性相互作用に強い影響を与える.
- 極群のアイデンティティは,水害性相互作用の調節の大きさの決定的な決定因子です.
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