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Updated: Jan 6, 2026
01:37
Mitochondria
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心臓代謝臨床試験からの共有データと利用
Muthiah Vaduganathan1, Amulya Nagarur2, Arman Qamar3
1Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA (M.V., A.Q., D.L.B.). mvaduganathan@bwh.harvard.edu.
Circulation
|November 15, 2017
まとめ
心臓代謝試験のための患者レベルのデータ共有は利用可能だが,十分に活用されていない. データの共有が広く支持されているにも関わらず,アクセスできた試験は少ないし,出版に至った分析はさらに少ない.
科学分野:
- 心臓病科
- 内分泌学
- 臨床薬理学
背景:
- 患者レベルでの臨床試験データ共有は広く支持されています.
- 心臓代謝疾患における共有データの利用に関する情報は限られている.
研究 の 目的:
- 心臓代謝疾患に焦点を当てた臨床試験から得られた患者レベルのデータの利用可能性と利用率を評価する.
主な方法:
- ClinicalStudyDataRequest.comという 13の製薬会社のデータを持つプラットフォームからデータを抽出しました.
- 74の治療法と398, 925人の患者を対象とした,心臓代謝療法を評価した試験が含まれています.
主要な成果:
- 537件の心臓代謝試験のうち (合計の16%) 79件 (第3・4段階の29%) がデータアクセス要求を受けた.
- ほとんどのデータ要求者は学術的であり,提案は二次仮説に焦点を当てていました.
- この共有されたデータから 査読された記事は3つしか出版されなかった.
結論:
- 500件以上の試験のデータがあるにもかかわらず,アクセスと公表率は低いままです.
- 研究者がアクセスできたのは,心臓代謝試験と第3・4段階の試験のほんの一部である.
- 共有された心臓代謝臨床試験のデータからの出版出力は,現在では無視できます.
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