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変異したscFv抗体断片のダイナミックカップリングを安定化および不安定化効果に分解する

Azhagiya Singam Ettayapuram Ramaprasad1, Shahid Uddin2, Jose Casas-Finet3

  • 1Department of Physics and Optical Science, University of North Carolina at Charlotte , Charlotte, North Carolina 28223, United States.

Journal of the American Chemical Society
|November 16, 2017
PubMed
まとめ

抗体ダイナミクスは,ある部分の安定化または不安定化が,全体構造にどのように影響するか明らかにします. リンカーと補完性決定領域 (CDR) は複雑な反応を示し,抗体機能におけるダイナミックアロステリーを示唆する.

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