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In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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宿主防御を抑制するシゲラエフェクターによるGBPのユビキチン化と分解

Peng Li1,2, Wei Jiang2, Qin Yu2

  • 1Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, National Institute of Biological Sciences, Beijing, 102206, China.

Nature
|November 17, 2017
PubMed
まとめ

シゲッラ・フレックスネリ菌は,IpaH9.8エフェクタを使用して,ガニラート結合タンパク質 (GBP) を分解することによって,免疫防御を回避する. このプロセスを妨害することで GBPは細菌の増殖を抑制し,宿主と病原体の相互作用における重要なメカニズムを明らかにします

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