関連する実験動画

Updated: Feb 18, 2026

Discrimintion and Mapping of the Primary and Processed Transcripts in Maize Mitochondrion Using a Circular RT-PCR-based Strategy
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Discrimintion and Mapping of the Primary and Processed Transcripts in Maize Mitochondrion Using a Circular RT-PCR-based Strategy

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ミトコンドリア転写開始の構造的基礎

Hauke S Hillen1, Yaroslav I Morozov2, Azadeh Sarfallah2

  • 1Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

Cell
|November 18, 2017
PubMed
まとめ

研究者はヒトのミトコンドリア転写開始メカニズムを明らかにした. 結晶構造は,トランスクリプション因子TFAMとTFB2Mが,ミトコンドリアRNAポリメラーゼ (mtRNAP) によってプロモーターの認識と開封をどのように促進するかを明らかにする.

キーワード:
開始する入門複合体ミトコンドリアPOLRMT についてポリメラーゼTEFM についてTFAM についてTFB2Mトランスクリプション

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Transcription Initiation

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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
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Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
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