リスクの高いビジネス: ストレスによる意思決定に影響を与える回路
Amy F T Arnsten1, Daeyeol Lee2, Christopher Pittenger3
1Departments of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Child Study Center, Yale University School of Medicine, New Haven, CT 06510, USA.
Cell
|November 18, 2017
まとめ
ストレスは前頭前皮質の ストライタル回路の制御を 妨害し 潜在的な損失に対して 動物を無感覚にすることで 危険な決断へと導きます このメカニズムは ストレス関連の薬物乱用と 自動行動の抑制を解明するかもしれません
科学分野:
- 神経科学
- 行動科学
背景:
- ストレスが意思決定に 影響を及ぼすことは知られています
- ストレスに起因する 行動変化の背後にある 神経学的メカニズムを理解することは 極めて重要です
研究 の 目的:
- 神経回路レベルでの意思決定に ストレスがどう影響するかを調べる
- ストレスに関連する行動における前頭前皮質と状皮質の相互作用の役割を明らかにする.
主な方法:
- この研究では動物モデルを使って 神経回路の活性を調べた.
- ストレスの下で前頭前皮質の状回路に対する抑制制御を調査した.
主要な成果:
- ストレスは前頭前皮質の抑制機能を妨害することが判明した.
- この干渉により動物は 潜在的な悪影響や損失に対して無感覚になった.
- ストレスは リスクの高い意思決定を促す 直接的な神経経路を示唆しています
結論:
- ストレスは前頭前皮質 - 経路の機能を 変えて実行制御を妨げます
- この神経の機能障害は 薬物乱用のような ストレスに起因する症状の元にあるかもしれません
- このメカニズムは トゥーレット症候群のティックのような 自動行動の抑制を解明することもできます
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