関連する実験動画

Updated: Feb 18, 2026

ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast
07:31

ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast

Published on: June 30, 2022

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Saccharomyces cerevisiaeからの後触媒スプライソームの構造

Rui Bai1, Chuangye Yan1, Ruixue Wan1

  • 1Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China.

Cell
|November 21, 2017
PubMed
まとめ

発酵後スプリセソーム (P複合体) の冷凍-EM構造を決定し,mRNA前スプリッシングでエクソンがどのように結合されるかを明らかにしました. この構造は,RNA-RNAの接触とスペライス・ジャンクションでの特定の核酸認識を明確にします.

キーワード:
3′SSの認識DEAH-box ATPase/ヘリカースP複合体Prp22 について原子構造クリオ・エムエクソン結合mRNAの放出ポストカタリティック・スプレイスmRNA前スプライシング

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