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Updated: Jun 23, 2026

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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"MAP2K3-p38シグナル伝達を抑制することで心筋線維細胞特異活性化トランスクリプションファクター3が心不全を予防する"という記事に関する書簡に対するDu et alの回答

Jie Du1, Xin-Liang Ma2, Yulin Li1

  • 1Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, China (J.D., Y.L.L., B.Y.C.).

Circulation
|November 22, 2017
PubMed
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No abstract available in PubMed .

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MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...