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大腸がんにおけるFusobacteriumの持続性と抗生物質反応の分析

Susan Bullman^1,2, Chandra S Pedamallu^1,2, Ewa Sicinska¹

¹Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)

|November 25, 2017

まとめ

この研究では,Fusobacterium nucleatum細菌とその関連する微生物群が結腸直腸がんの転移において安定していることが判明しました. Fusobacteriumを標的とした抗生物質治療は腫瘍の成長を減少させ,大腸がんに対する潜在的な抗菌療法を示唆しています.

科学分野:

微生物学
腫瘍学
胃腸内科

背景:

結腸直腸がん (CRC) は細胞と微生物の複合体である.
Fusobacterium nucleatumは,CRC組織に見られる一般的な細菌です.

研究の目的:

結腸直腸がんの転移におけるFusobacterium微生物群の安定性を調査する.
Fusobacteriumを抗菌剤で治療する可能性を検討する.

主な方法:

転移性病変におけるフーソバクテリアの局所化を分析するためのインシト混合化.
人間の大腸内腺がんのマウス異種移植モデル.
メトロニダゾールによる抗生物質治療で,フーソバクテリアと腫瘍の増殖への影響を評価する.

主要な成果:

Fusobacteriumとその関連した微生物群 (Bacteroides,Selenomonas,Prevotella) は遠隔転移において安定していた.
Fusobacteriumは主に転移部位にある癌細胞と関連していた.
メトロニダゾール治療は,マウスモデルにおけるフーソバクテリアの負荷,癌細胞の増殖,腫瘍の増殖を減少させた.

結論:

結腸直腸がんの転移ではフーソバクテリアのコロニー化が維持され,微生物群の安定性を示しています.
Fusobacteriumを標的とした抗菌介入は,CRCの潜在的な治療戦略として有望である.

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