抗原の処理とプレゼンテーションにおけるIa関連インヴァリアント鎖の役割
B Stockinger1, U Pessara, R H Lin
1Basel Institute for Immunology, Switzerland.
Cell
|February 24, 1989
まとめ
インヴァリアント鎖は,Tヘルパー細胞のプレゼンテーションのためのネイティブ抗原を処理するために重要である. 線維芽細胞でのその発現は,断片化されたものとは異なり,無傷な抗原の提示を可能にします.
科学分野:
- 免疫学 免疫学とは
- 分子生物学は分子生物学である.
- 細胞生物学 細胞生物学
背景:
- Tヘルパー細胞の活性化は,抗原のプレゼンテーションに依存しています.
- 細胞コンパートメントにおける抗原処理は不可欠ですが,そのメカニズムは完全に理解されていません.
- クラスIIのMHC関連インヴァリアント鎖は,抗原処理を媒介する潜在的な候補である.
研究 の 目的:
- 抗原処理における不変連鎖の役割を調査する.
- インヴァリアントチェーンがT細胞にネイティブ抗原のプレゼンテーションを容易にするかどうかを判断する.
主な方法:
- 線維芽細胞は,IIクラス遺伝子で感染した.
- 繊維芽細胞は,不変の鎖遺伝子で超伝染された.
- 抗原プレゼンテーション能力は,特定のT細胞クローンと様々な抗原形態 (ネイティブ,断片化) を使用して評価されました.
- クロロクイン治療は,細胞区画の役割を評価するために使用されました.
主要な成果:
- 不変連鎖を発現する線維芽細胞は,低濃度であっても,ネイティブ抗原を効果的に提示した.
- 両方の感染した線維芽細胞タイプは,断片化された抗原 (C5ペプチド,ウイルスペプチド) を提示した.
- 欠損した抗原ではなく,欠損した抗原のプレゼンテーションは,クロロクインによってブロックされました.
- li31またはli41ポリペプチドの発現は,無傷な抗原プレゼンテーションに十分であった.
結論:
- インヴァリアント鎖は,ネイティブ抗原の処理に不可欠な細胞構成要素である.
- インヴァリアント鎖は,クロロクインに敏感な細胞区画内の抗原処理を媒介する.
- インヴァリアント鎖は,暗号化されたポリペプチドli31およびli41を通じて,Tヘルパー細胞に依存した抗原のプレゼンテーションにおいて重要な役割を果たします.
関連する概念動画
Antigens Involved in Adaptive Immunity
1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
Diversity of Antigen Receptors
2.1K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K
Antigen Presenting Cells
3.7K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.7K
Antigen Processing Pathways
2.9K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
2.9K
T Cell Activation and Clonal Selection
13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
B Cell Activation and Differentiation
14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K


