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Updated: Feb 18, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
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Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells

Published on: March 9, 2012

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リモートサイトリン酸化による内在的に乱れた脚架タンパク質,LATへのGrb2のアロステリック変調

William Y C Huang1,2, Jonathon A Ditlev1,3, Han-Kuei Chiang2

  • 1The Howard Hughes Medical Institute Summer Institute, Marine Biological Laboratory , Woods Hole, Massachusetts 02543, United States.

Journal of the American Chemical Society
|November 29, 2017
PubMed
まとめ

T細胞受容体 (TCR) のシグナル伝達において重要な役割を果たすLATタンパク質の多価リン酸化は,Grb2結合を調節するアロステリックメカニズムを明らかにする. この複雑なプロセスは信号伝送を妨げ,効率的なT細胞活性化には複数のリン酸化イベントが必要です.

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