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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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クラスCのラジカルS-アデノシル-l-メチオニンのチアゾルメチル移転酵素のメカニズム

Zhengan Zhang1,2, Nilkamal Mahanta1,3, Graham A Hudson1

  • 1Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

Journal of the American Chemical Society
|December 1, 2017
PubMed
まとめ

この研究は,チオペプチド抗生物質のバイオシンセシスに不可欠なC級ラジカルS-アデノシルメチオニン (rSAM) メチルトランスフェラーゼ,TbtIのメカニズムを明らかにしています. 2つのSAM分子と異なる水素転送ステップを含む新しいメチル化経路を発見した.

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