オステオブラストは,がんを誘発するSiglecF高中性粒子を遠隔的に肺腫瘍に供給する
Camilla Engblom1,2, Christina Pfirschke1, Rapolas Zilionis3,4
1Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
Science (New York, N.Y.)
|December 2, 2017
まとめ
肺アデノカルシノーマは,腫瘍促進性中性粒子を供給する骨の骨芽細胞を遠隔的に活性化します. オステオカルシン発現細胞の減少は中性粒子の反応と肺腫瘍の成長を抑制する.
科学分野:
- 腫瘍学
- 免疫学
- 骨の生物学
背景:
- 腫瘍の骨髄細胞は癌の成長を促すことができます.
- 腫瘍の成長における全身の宿主環境の役割はよく理解されていません.
- 局所的な免疫-腫瘍相互作用は広範に研究されています.
研究 の 目的:
- 組織的な宿主環境が肺腺癌の増殖に与える影響を調査する.
- 非転移性肺がんが骨の微小環境に影響を与えるメカニズムを特定する.
- オステオブラストと特定の中性粒子のサブセットが癌の進行における役割を調査する.
主な方法:
- マウスと70人の癌患者の肺腺がんを研究した.
- 癌に起因する骨構造の変化を調査した.
- オステオカルシン発現 (Ocn+) オステオブラスト細胞の役割を分析した.
- Ocn+細胞が腫瘍に浸透するSiglecFhigh中性粒子の影響を調べました.
- 腫瘍増殖に対する Ocn+ 細胞数の減少の影響を評価した.
主要な成果:
- 肺アデノカルシノーマは,骨転移なしでも,骨のストロマ活動を増大させる.
- オステオカルシン発現する骨質細胞は,このがん誘発性骨のフェノタイプに関与しています.
- Ocn+細胞は,ガンを引き起こす高中性粒子を遠隔的に供給する.
- Ocn+細胞の数を減らすことで,中性粒子の反応と肺腫瘍の増殖が抑制されました.
結論:
- オステオブラストは肺がんの進行を 遠隔的に制御します
- SiglecFの高い中性粒子は,骨格細胞主導の突起性応答における重要な骨髄細胞エフェクターである.
- オステオブラストと中性粒子の相互作用をターゲットにすることで,肺がんの新たな治療戦略が提供される可能性があります.
さらに関連する動画
関連する概念動画
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:40Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.