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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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合成トランスクリプション延長因子は,抑圧的なクロマチンの横断でトランスクリプションを許可する

Graham S Erwin1, Matthew P Grieshop1, Asfa Ali1

  • 1Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

Science (New York, N.Y.)
|December 2, 2017
PubMed
まとめ

科学者は遺伝子発現を制御するために合成転写延長因子 (Syn-TEFs) を開発した. Syn-TEF1はGAAのリピートに特化したもので,フリードライヒのアタキシアにおけるフラタキシン遺伝子発現を再活性化します.

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