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鉄触媒によるN-ヘテロアレンの1,2-選択的水酸化

Fanjun Zhang¹, Heng Song¹, Xuewen Zhuang¹

¹School of Chemistry and Chemical Engineering, Shandong University , No. 27 South Shanda Road, Jinan 250100, China.

Journal of the American Chemical Society

|December 2, 2017

まとめ

新しい二鉄複合体は,ピナコルボランを用いてN-ヘテロアレンの水酸化を触媒化する. このプロセスは,非常に地域選択的なN-ボリレイテッドの1,2-減量製品を生成し,B-H結合の割れが主要な速度決定段階である.

科学分野:

有機金属化学
カタリシス
有機合成

背景:

N-ヘテロアーレンは,医薬品や材料における重要な構造モチーフである.
選択的な機能化のための効率的な方法は非常に求められています.
ボロンを含むグループを導入する多用途の経路を提供している.

研究の目的:

N-ヘテロアレンの水酸化のための新しい触媒システムを開発する.
ダイアイロン複合体の触媒活性と選択性を調査する.
水酸化反応のメカニズムを解明する.

主な方法:

N2ブリッジされた二鉄複合体の合成と特徴: [Cp*(Ph2PC6H4S) Fe]2(μ-N2) (1).
ピナコルボランを用いた様々なN-ヘテロアレンの触媒性水酸化.
速度決定のステップを決定するためのメカニズム研究.

主要な成果:

ダイアイロン複合体 (1) は,N-ヘテロアレンの水酸化を効果的に触媒化する.
この反応により,高地域選択性を持つN-ボリル化1,2-減少産物が生成される.
カタリシスの開始には,鉄の中心へのN-ヘテロアレン調整が含まれます.
利率決定のステップとしてB-H債券の分割が特定されました.

結論:

新しい二鉄触媒は,N-ヘテロアレンを効率的かつ地域選択的に水酸化することができる.
この研究は,B-H結合の分裂を重要視して,触媒機構の洞察を提供します.
この研究は,機能化されたN-ヘテロアレン誘導体にアクセスするための貴重な合成ツールを提供します.

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