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Updated: Feb 17, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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エプシン依存性リガンド内細胞化は,強制的にノッチを活性化させる

Paul D Langridge1, Gary Struhl1

  • 1Department of Genetics and Development, Columbia University, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.

Cell
|December 2, 2017
PubMed
まとめ

ノッチ受容体の活性化には,エプシンによるDSLリガンド内細胞化が必要であり",リサイクル"モデルよりも"引き寄せ"モデルをサポートする. ノッチ結合後のリガンド内細胞化は,分裂と信号伝送に不可欠である.

キーワード:
DSL/ノッチ・シグナルノッチクラトリンデルタエンドサイトーシスエプシンフォースフォン・ウィレブランド因子

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