発達における長期的な行動パターンと個性の神経調節制御

Shay Stern¹, Christoph Kirst², Cornelia I Bargmann³

¹Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA.

Cell

|December 5, 2017

まとめ

この研究は発達プログラムがワームの行動を形作る一方で個々のワームが独特で遺伝的でないバイアスを示すことを示しています神経調節器は行動の軌跡と個性を微調整します

科学分野:

神経科学
発達生物学
行動の遺伝

背景:

動物の行動は発達プログラムと個々の変化によって形作られる.
これらの因子の相互作用を理解することは行動の複雑さを理解する上で極めて重要です

研究の目的:

発達プログラムと個別の変化がケノラブディティス・エレガンスの行動に与える影響を調査する.
行動軌跡と個性を影響する分子機構と神経調節系を特定する.

主な方法:

単一のネマトドス (Caenorhabditis elegans) を,その完全な発達経路を通して監視する.
高解像度で自発的な採食行動を定量化しています
特定の神経調節物質 (ドーパミン,セロトニン,NPR-1,DAF-7) が行動パターンに及ぼす影響を分析する.

主要な成果:

発達段階を超えて,再現可能でステレオタイプ化された自発的な餌探し行動が観察されました.
ドーパミンやセロトニンのような神経調節物質は行動軌道にステージ特有の影響を及ぼします
個人のサブセットは,同位体背景から独立して一貫した,非遺伝的行動バイアスを示した.
神経調節システムは非遺伝的個性の度合いを調節することが判明した.

結論:

C.elegansの行動的発達は,神経調節器によって影響されるモジュール型の時間的プログラムによって制御される.
非遺伝的個体多様性は,持続的な行動パターンを形成する上で重要な役割を果たします.
神経調節は発達と個人の行動の両方を動的に制御します

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