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Updated: Feb 17, 2026

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
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空間時間的な遺伝子発現軌跡は,人間の皮質の発達階層を明らかにします

Tomasz J Nowakowski1,2,3, Aparna Bhaduri1,2, Alex A Pollen4,2

  • 1Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA. tomasz.nowakowski@ucsf.edu arnold.kriegstein@ucsf.edu.

Science (New York, N.Y.)
|December 9, 2017
PubMed
まとめ

研究者はヒトの脳内の細胞発達のマッピングを行い, 放射性膠質の成熟と神経生成のための 独特の遺伝子発現経路を明らかにしました これは脳の発達初期に 多様なニューロンが 発生する様子を明らかにしています

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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