前頭前皮質からの下降プロジェクションにおける社会空間コードの組み合わせ

Malavika Murugan¹, Hee Jae Jang¹, Michelle Park²

¹Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.

Cell

|December 12, 2017

まとめ

研究者らは,哺乳類の社会的行動と社会空間的学習に不可欠なプレリンビック皮質 (PL) ニューロンを核アクンベンズ (NAc) に投影することを特定しました.

科学分野:

神経科学
行動神経科学
システム神経科学

背景:

哺乳類の生存と繁殖には社会的行動が不可欠です
プレリンビック皮質 (PL) は,中央前頭皮質の領域で,社会的行動に役割を果たすことが知られているが,関連する特定のニューロン集団は不明である.

研究の目的:

PL内の異なるニューロンのサブ集団とその下流ターゲットを特定する.
社会的行動と社会空間的学習の調節における特定の PL ニューロンのサブポピュレーションの役割を調査する.

主な方法:

PLニューロンのサブ集団の解剖学的および分子的特徴.
ダウンストリーム領域をターゲットにする:核アキュンベンス (NAc),桃体,腹部テグメンタル領域
PL-NAcニューロンの選択的活性化と記録
ニューロンの活動に空間的特異的な操作をします

主要な成果:

PLには,NAc, amigdala, ventral tegmental領域に投影する解剖学的に分別のあるサブ集団が含まれています.
PL-NAcニューロンの活性化が,他のサブポピュレーションではなく,社会的ターゲットに対する偏好が低下した.
PL-NAcニューロンは,社会的調査中に空間的に特定の活動を表します.
PL-NAcニューロンの空間特異的な操作を通じて,社会空間的関連形成の双方向的調節.

結論:

PL-NAcニューロンは社会的情報と空間情報の両方を伝達します
PL-NAcニューロン内の社会的・空間的情報の統合は,社会的・空間的学習にとって極めて重要です.
これらの発見は脳が複雑な社会的行動をサポートする新しいメカニズムを明らかにしています

キーワード:

カルシウムイメージング中部前頭皮質コア・アクンベンズオプトジェネティクス社会的行動

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