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Updated: Feb 17, 2026

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
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Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

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標的型トランスメブランBAX阻害剤 モチーフ含有 1 病理性心筋縮を緩和する

Ke-Qiong Deng1,2,3,4, Guang-Nian Zhao2,3,5,4, Zhihua Wang1,2,3,4

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, China (K.-Q.D., Z.W., P.Z., Z.-G.S., H.L.).

Circulation
|December 13, 2017
PubMed
まとめ

トランスメンブランBAX阻害モチーフ1 (TMBIM1) が含まれており,トール型受容体4 (TLR4) のリソソーム性分解を強めることで,心臓高縮から保護します. TMBIM1をターゲットにすることで 心不全の治療戦略が生まれます

キーワード:
トール型受容体 4心不全ハイパートロフィーリソソームマルチビキュラー体

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