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関連する概念動画

RNA Structure01:23

RNA Structure

79.3K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.3K
RNA Structure01:19

RNA Structure

7.8K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
7.8K
Nucleic Acid Structure01:25

Nucleic Acid Structure

9.5K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
9.5K
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

16.8K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
16.8K
The DNA Replication Fork01:02

The DNA Replication Fork

41.3K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
41.3K
Nucleic acids02:43

Nucleic acids

194.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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関連する実験動画

Updated: Feb 16, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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単一鎖のDNAとRNAのオリガミ

Dongran Han1,2, Xiaodong Qi3,4, Cameron Myhrvold1,2

  • 1Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 16, 2017
PubMed
まとめ

研究者たちは 複雑で結び目のない形に 折りたたまれる単一のDNAやRNAを 設計する新しい方法を開発しました この進歩により,再現可能な核酸ナノ構造を持つ,スケーラブルでボトムアップなナノテクノロジーが可能になります.

さらに関連する動画

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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関連する実験動画

Last Updated: Feb 16, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

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Folding and Characterization of a Bio-responsive Robot from DNA Origami
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科学分野:

  • バイオテクノロジー
  • ナノテクノロジー
  • 合成生物学

背景:

  • 定義された構造にポリマーの自己折り畳みは生物学において極めて重要です
  • 多コンポーネントの自己組み立てにより 複雑な合成ナノ構造が生まれました
  • 単分子折り畳み戦略は複雑さとスケーラビリティの限界に直面しています.

研究 の 目的:

  • 単一の核酸鎖を設計し合成するための枠組みを確立し, 任意の,複雑で結びつきのない形に自己折り畳む.
  • 大規模で複製可能なナノ構造を作り出すための 単分子折り畳みの実現可能性を実証する.

主な方法:

  • 単分子折り畳み経路の予測と設計のためのコンピューティングフレームワークの開発.
  • マルチキロベース単鎖DNAとRNA構造の実験合成
  • 設計された核酸鎖のインビトロおよびインビボ (生体細胞) 複製

主要な成果:

  • 多様で複雑で結ばれていない単一鎖の核酸ナノ構造の成功設計と実験構築.
  • ~10,000核酸のDNA構造と ~6000核酸のRNA構造の作成
  • 活体細胞内でも,これらの構造が容易に複製されるという証拠です.

結論:

  • 単分子折り畳みは,複雑で複製可能な核酸ナノ構造を構築するための実行可能で一般的な戦略です.
  • このアプローチは,ボトムアップナノテクノロジーの設計空間と材料のスケーラビリティを大幅に拡大します.
  • 開発された枠組みは,カスタム型の核酸ナノマテリアルの作成を容易にする.