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細胞の吸収を大幅に改善するために,変形可能な空洞周期性メソポラス有機ナノカプセル
Zhaogang Teng1,2, Chunyan Wang1, Yuxia Tang1
1Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University , Nanjing, 210002 Jiangsu, P. R. China.
Journal of the American Chemical Society
|December 28, 2017
まとめ
研究者らは,細胞の吸収を向上させるため,新型の可変性空洞周期性メソポラス・オルガノシリカ (HPMO) ナノカプセルを開発した. これらの柔軟なナノキャリアは,がん治療の応用において,薬剤の投与効率を大幅に改善します.
科学分野:
- 材料科学
- ナノテクノロジー
- バイオメディカルエンジニアリング
背景:
- メソポラス固体は 薬物投与と腫瘍治療に不可欠です
- 細胞の吸収は粒子の変形性によって大きく影響されます.
- 変形性メソポラス材料の合成は依然として大きな課題です.
研究 の 目的:
- 新しい形状変形可能な空洞周期性メソポラス・オルガノシリカ (HPMO) ナノカプセルを合成する.
- 細胞の吸収と薬物の投与に対する変形性の影響を調査する.
- これらのナノカプセルが がん治療における可能性を 評価するためです
主な方法:
- HPMOナノカプセルの合成 優先エッチング手法
- ナノカプセル特性の特徴 (サイズ,表面積,毛穴サイズ,殻の厚さ,ヤングのモジュール).
- 液体細胞電子顕微鏡を用いたMCF-7細胞における細胞吸収の評価
- ドクソルビシン (DOX) を投与して薬の投与を評価する.
主要な成果:
- 変形可能なHPMOナノカプセルを合成し,均一なサイズ,高表面積,および大きな毛穴量を達成しました.
- HPMOナノカプセルは,固体 (251MPa) に比べてYoungのモジュール (3.95MPa) が著しく低く,高い柔軟性を示した.
- 変形性HPMOは,形質を変化させ,MCF-7細胞への侵入を促進することで,細胞の吸収を26倍に増加させました.
- DOXを搭載したHPMOナノカプセルは,MCF-7細胞に強力な殺菌効果を示した.
結論:
- 新しい好ましいエッチング法により,初めて形状が変形可能なHPMOナノカプセルを合成することが可能になった.
- HPMOの固有の柔軟性は,細胞内化を大幅に強化します.
- これらの変形可能なHPMOナノカプセルは 先進的な薬物投与と癌治療に 大きな希望を示しています
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