ニューレキシンは,成熟した性二形ニューロンの可塑性を制御する
Michael P Hart1, Oliver Hobert1
11Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York, USA.
Nature
|January 12, 2018
まとめ
C. elegansでは,成人オスはGABAを放出するDVBニューロンで経験に依存する神経の可塑性を発揮し,交尾行動を変化させます. この性二形態の可塑性にはニューライトの添加があり,ニューレキシンとニューロリギンによって制御されます.
科学分野:
- 神経科学
- 発達生物学
- 行動生物学
背景:
- ニューロンの可塑性は発達と成人期に不可欠であり,シナプス構造とニューロンの接続に影響します.
- ニューロンの可塑性に対する性の影響は,特に形態学的レベルでは,ほとんど研究されていない.
研究 の 目的:
- ニューロンの可塑性における セックスの役割を調査する
- 経験に依存する神経細胞の形態学的変化の背後にあるメカニズムを解明する.
主な方法:
- モデル生物として使用した
- GABAを放出するDVBニューロンを 経験依存性および性二形性可塑性について調べました
- 神経細胞の成長におけるシナプス前ニューレキシンとシナプス後ニューロリギンの役割を調査した.
主要な成果:
- 大人の雄のC. elegansのDVBニューロンは,神経細胞のストキャスティックとダイナミックな追加を示す.
- このニューライトの追加はシナプスの再配線とDVBニューロンの機能的なスイッチにつながる.
- 神経細胞の増殖はニューレキシンによって促進され,ニューロリジンによって抑制され,新しい相互作用が明らかにされます.
結論:
- セックスは神経の可塑性に大きく影響し,DVBニューロンの性二形態的形態的変化につながります.
- 経験とポストシナプス活動は,DVBニューロン機能と男性の交尾行動を変えることができます.
- ニューレキシンとニューロリギンは,ヒトの疾患に関連する神経の可塑性の保存メカニズムを媒介する.
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