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アルコールと内生アルデヒドは染色体を破壊し,幹細胞に変異を起こします

Juan I Garaycoechea1, Gerry P Crossan1, Frédéric Langevin1

  • 1MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Nature
|January 12, 2018
PubMed
まとめ

アルコールの代謝物質であるアセタルデヒドは,血液幹細胞のDNAを損傷し,変異とゲノム不安定を引き起こします. P53遺伝子の削除は 細胞の生存を救いますが 変異パターンは救いません

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