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Updated: Feb 15, 2026

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
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Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

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脂肪アシルの認識と統合膜S-アシルトランスファーゼによる転送

Mitra S Rana1, Pramod Kumar1, Chul-Jin Lee1

  • 1Cell Biology and Neurobiology Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|January 13, 2018
PubMed
まとめ

DHHCパルミトイルトランスフェラーゼは,細胞シグナル伝達における重要な酵素である. 構造的な洞察は,膜-細胞溶液界面での活性部位を明らかにし,基板特異性を説明し,将来の薬剤設計を導く.

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