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Updated: Feb 15, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
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メバロナート経路による訓練された免疫の代謝誘導

Siroon Bekkering1, Rob J W Arts2, Boris Novakovic3

  • 1Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands; Department of Experimental Vascular Medicine, Academic Medical Centre, Amsterdam, the Netherlands.

Cell
|January 13, 2018
PubMed
まとめ

メタボリックシグナル,特にメバロナートは,重要なシグナル伝達経路を活性化することによって,骨髄細胞で訓練された免疫を誘導します. スタチンはこのプロセスを阻害し,HIDS患者におけるメバロナート蓄積は訓練された免疫フェノタイプを引き起こす.

キーワード:
HIDS についてエピジェネティクスハイパーIgD症候群免疫代謝生まれながらの免疫記憶マクロファージメタボリズムメバロナートキナーゼ欠乏症モノサイト訓練された免疫

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