西洋の食生活はNLRP3依存の先天性免疫再プログラムを引き起こす
Anette Christ1, Patrick Günther2, Mario A R Lauterbach3
1Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA.
Cell
|January 13, 2018
まとめ
免疫細胞を再プログラムして 訓練された免疫を作り出すのです この再プログラムにより 免疫細胞の反応と増殖が強化され 炎症性疾患に 寄与する可能性があります
科学分野:
- 免疫学
- エピジェネティクス
- 代謝疾患
背景:
- トレーニングされた免疫には 生まれつきの免疫細胞の 長期的エピジェネティック再プログラムが含まれており 二次感染に対する反応が強化されます
- ダイエットによって誘発されるような無菌の炎症トリガーの役割は,訓練された免疫の開始において完全に理解されていません.
研究 の 目的:
- 炎症を誘発する無菌薬が 訓練された免疫を誘発するかどうかを調べる
- ダイエット誘発型免疫の仕組みと 骨髄細胞機能への影響について
主な方法:
- Ldlr-/- マウスの体内炎症を誘発するために西食 (WD) を使った.
- 骨髄細胞の反応と 複写体と 遺伝子の再プログラミングを分析した
- 酸化低密度リポプロテイン (oxLDL) とリポポリサカリド (LPS) で訓練されたヒトモノサイトにおける定量的な特質ロカス (QTL) 分析を行った.
- NLRP3-/-/Ldlr-/-マウスを用いてNLRP3炎症体の役割を評価した.
主要な成果:
- WDの摂取は全身の炎症を誘発し,ダイエットが逆転した後でも,長期間増強された骨髄細胞反応を引き起こしました.
- WDは,骨髄性原始細胞のトランスクリプトミックとエピジェノミックの再プログラムを引き起こし,増殖と先天的な免疫反応を増加させた.
- QTL分析とNLRP3-/ Ldlr-/ マウスのデータは,NLRP3炎症体がWD誘発の訓練された免疫,炎症,および骨髄原菌の増殖を媒介することを示した.
結論:
- 西洋の食生活が誘発した 無菌の炎症は 骨髄細胞の訓練された免疫を 引き起こすのです
- NLRP3炎症ゾームは,食事誘発の訓練免疫および関連する骨髄細胞再プログラムの主な媒介である.
- このNLRP3媒介の訓練免疫は,炎症性疾患における訓練免疫の有害な効果に寄与する可能性があります.
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