ドナー・レセプター・コーディネーション・インタラクションによって誘発されるポリメリックミケルの高い薬物負荷と小量の負荷効率
Shixian Lv1,2, Yuchen Wu1, Kaimin Cai2
1Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University , Suzhou 215123, China.
Journal of the American Chemical Society
|January 16, 2018
まとめ
研究者は薬剤の投与を 強化するための高度なポリマーミセルを開発しました この新しい方法は,超高濃度の薬剤を投与し,がん細胞の放出を標的とし,有効性を向上させ,毒性を低下させます.
科学分野:
- バイオマテリアル科学
- ナノテクノロジー
- 薬物投与システム
背景:
- ポリメリックミセルは水害性薬物の投与に不可欠ですが,薬物の負荷,均一性,安定性,および放出に関する課題に直面しています.
- 既存の方法は,高い薬剤封じ込み効率と制御された放出を達成するためにしばしば苦労します.
研究 の 目的:
- 超高薬量のポリマーミセルを製造するための新しい戦略を開発する.
- 癌細胞のコロイドの安定性,均一なサイズ,標的の薬物放出のためにミセルを設計する.
主な方法:
- ペンダントフェニルボロン酸単位によるアンフィフィリック共ポリマーの合成.
- ポリマー-薬物協調相互作用 (ドナー-受容体) を薬の封じ込みに利用する.
- 薬物の負荷,サイズ,安定性を含むミセルの特性.
- 反応性酸素種 (ROS) に対する薬剤放出運動の評価
主要な成果:
- ドクソルビシンでは,超高の薬物負荷 (約50%) と,ほぼ定量的な負荷効率 (>95%) を達成した.
- 形成されたミセルは均一なサイズと優れたコロイドの安定性を示した.
- 癌細胞における高レベルのROSによって誘発される有効で選択的な薬剤の放出が実証された.
- エピルルビシンやイリノテカンのような他の電子ドナー薬の応用の可能性を示した.
結論:
- 開発されたポリマー・ドラッグ・コーディネーション・ストラテジーは,ポリマーミセルの高い薬物負荷のためのシンプルで堅固な方法を提供します.
- エンジニアリングされたミセルは,標的の薬物投与と全身の毒性を減らすことにより,抗がん効果を高めます.
- このプラットフォームは,防水性抗癌薬の治療効果を向上させる大きな希望を持っています.
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