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Updated: Feb 15, 2026

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

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LXR/ApoEの活性化は,がんにおける先天性免疫抑制を抑制する

Masoud F Tavazoie1, Ilana Pollack1, Raissa Tanqueco1

  • 1Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.

Cell
|January 17, 2018
PubMed
まとめ

肝臓X受容体 (LXR) アゴニストによる骨髄系抑制細胞 (MDSCs) を標的とした治療は,がん免疫療法を強化することができる. このアプローチは免疫抑制細胞を減少させ,前臨床モデルと第1相試験で抗腫瘍T細胞の反応を高めます.

キーワード:
アポエ (ApoE)LRP8 についてLXR についてMDSC について癌について臨床試験免疫療法ミエロイド核ホルモン受容体腫瘍免疫学

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