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NT5C2変異性急性リンパ性白血病におけるクローン進化メカニズム

Gannie Tzoneva1, Chelsea L Dieck1, Koichi Oshima1

  • 1Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA.

Nature
|January 18, 2018
PubMed
まとめ

NT5C2遺伝子の機能獲得変異は,化学療法に対する耐性を引き起こすことで,急性リンパ性白血病 (ALL) を再発させた. IMPDHを阻害することで,NT5C2変異性ALLを治療する見込みがある.

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