オーガニックシンセシスのデジタル化
Philip J Kitson1, Guillaume Marie1, Jean-Patrick Francoia1
1WestCHEM, School of Chemistry, The University of Glasgow, Glasgow G12 8QQ, UK.
Science (New York, N.Y.)
|January 20, 2018
まとめ
研究者は3Dプリントした プラスチック製の装置を開発し 精細な化学品や医薬品を製造しました このアプローチにより 専門施設の外で現地製薬が可能になり 製薬の製造がより容易になります
科学分野:
- 化学工学
- 製薬産業
- 3Dプリント技術
背景:
- 伝統的な化学薬品と医薬品の製造は,生産の時間軸が限られている大規模な資本集約的な施設に依存しています.
- 現存する方法は,局所化またはオンデマンドの精細化学品および医薬品の生産に重大な障壁をもたらします.
研究 の 目的:
- 3Dプリントの反応器装置を用いて細かい化学品や医薬品を製造するための新しいアプローチを提示する.
- ベンチスケール合成をデジタル形式に変換して自動化生産の実現可能性を実証する.
- 伝統的な専門施設の外で 薬の製造を可能にします
主な方法:
- 化学対コンピュータ自動設計 (ChemCAD) のアプローチを使用して,反応器のデジタル青写真を作成しました.
- 合成経路を統合した 3Dプリントされたプラスチック装置を開発しました
- γ-アミノバター酸受容体アゴニストである (±) -バクロフェンの合成を用いてそのプロセスを実証した.
主要な成果:
- 化学合成を行う 3Dプリント装置を成功裏に設計・製造しました
- ChemCADのアプローチは,ベンチスケールの合成をプラットフォーム独立のデジタルコードに変換することを可能にしました.
- この装置は (±) バクロフェンを成功裏に製造し,製造コンセプトを検証した.
結論:
- 開発されたアプローチは,局所的かつオンデマンドの製薬のための実行可能な方法を提供します.
- この技術は薬物の生産を分散させ 大規模な施設への依存を軽減する可能性を秘めています
- デジタルから物理的な製造のパラダイムは 入手可能な製薬合成のための新しい可能性を開きます
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