フォスフォエタノアミンセルロース:自然に生成される化学的に改造されたセルロース
Wiriya Thongsomboon1, Diego O Serra2, Alexandra Possling2
1Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Science (New York, N.Y.)
|January 20, 2018
まとめ
エシェリキア・コライは バイオフィルム構造に不可欠な 化学的に変化したセルロースを産生します NMRで特定されたこの新しいフォスフォエタノアミン変異は,細菌の細胞外マトリックス組立に不可欠です.
科学分野:
- 微生物学
- 生物化学
- 構造生物学
背景:
- セルロースは植物構造や 細菌のバイオフィルムに不可欠です
- バクテリアのセルロースの正確な組成と変異は,まだ完全に理解されていません.
研究 の 目的:
- エシェリキア・コリ菌のセルロースの化学的変化を特定する.
- バイオフィルムにおける改造されたセルロースの生産の基礎となる分子メカニズムを解明する.
主な方法:
- 固体核磁気共振 (NMR) スペクトロスコーピーは,無傷の細菌のセルロースを分析するために使用されました.
- 遺伝子解析により,セルロースの改変に関与する重要なタンパク質とシグナル伝達経路が特定されました.
主要な成果:
- エシェリキア・コライ菌のセルロースに ズウィトリアン系フォスフォエタノアミンの変化を発見した.
- BcsGをフォスフォエタノアミントランスファーゼとして識別し,その設置を制御するBcsE-BcsF-BcsG経路.
- この変異を起こす bcsEFG オペロンは,サルモネラのような他の細菌に保存されます.
結論:
- フォスフォエタノアミンセルロースは,E. coliのバイオフィルムの細胞外マトリクスの重要な成分です.
- この発見は,改造されたセルロースの生産の遺伝的および分子的基礎を明らかにしています.
- この発見により 細菌のセルロース生成を調節し 新しいセルロース材料を設計する 可能性が生まれます
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