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The normal, a continuous distribution, is the most important of all the distributions. Its graph is a bell-shaped symmetrical curve, which is observed in almost all disciplines. Some of these include psychology, business, economics, the sciences, nursing, and, of course, mathematics. Some instructors may use the normal distribution to help determine students’ grades. Most IQ scores are normally distributed. Often real-estate prices fit a normal distribution. The normal distribution is...
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超保存された強化剤は正常な発達のために必要である

Diane E Dickel1, Athena R Ypsilanti2, Ramón Pla2

  • 1Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Cell
|January 24, 2018
PubMed
まとめ
この要約は機械生成です。

哺乳類の正常な発達には極めて重要です マウスのArx遺伝子の近くで これらの配列を削除すると 微妙な神経学的および成長の欠陥が生じ 隠された重要性を明らかにしました

キーワード:
アークス脳の発達強化剤遺伝子調節ヒッポカンプスインビヴォノックアウトニューロンノンコーディング超保存された

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科学分野:

  • ゲノミクス
  • 発達生物学
  • 神経科学

背景:

  • 非コーディング超保存領域 (UCR) は,哺乳類のゲノム全体で高度に保存された配列である.
  • これらのUCRは,遠隔作用の強化剤として作用し,遺伝子発現を調節する.
  • 以前の研究では,UCRの削除が生存能力に直接的な影響を与えないことが示されました.

研究 の 目的:

  • 正常な発達における超保存強化剤の役割を調査する.
  • Arx 遺伝子の近くにある特定の UCR の機能的重要性を決定する.

主な方法:

  • ゲノム編集を活用して UCR の個体または組み合わせを欠いたノックアウトマウスを作成しました.
  • ゲノム全体で最も長いUCR,特にArx遺伝子の近くに焦点を当てた.
  • 変異したマウスの神経学的および成長現象を分析した.

主要な成果:

  • 単体または対のUCR削除を持つマウスは生存可能で肥沃でした.
  • ほぼ全ての突然変異のマウスは 神経学的異常と 成長の欠陥を示しました
  • ニューロン集団と構造的な脳の欠陥の 顕著な変化が観察されました

結論:

  • 哺乳類の正常な発達には必要不可欠である.
  • UCRにおける強力な配列保存は,標準的な実験条件では明らかでない適性欠陥を反映している可能性が高い.
  • これらの発見は,開発と進化におけるUCRの機能的重要性を強調しています.