トンドレノーン: 主な代謝が非常に制限されている細菌からの非典型的二次代謝物質

Aaron W Puri¹, Emily Mevers², Timothy R Ramadhar²

¹Department of Chemical Engineering, University of Washington , Seattle, Washington 98195, United States.

Journal of the American Chemical Society

|January 24, 2018

まとめ

研究者達は,メタンを酸化するバクテリアによって生成される新しい代謝物であるトゥンドレノンを発見しました. この発見はこれらの微生物が新しい天然化合物や生物合成経路を発見する可能性を強調しています

科学分野:

微生物学
生物化学
ゲノミクス

背景:

メタンを酸化するバクテリアは大気中のメタンの除去に不可欠です
これらの細菌は複雑で未熟な二次代謝能力を持っています
ゲノム分析により,新しい代謝産物発見の可能性が明らかになった.

研究の目的:

メチロバクター・トゥンドリパルドゥムの代謝産物であるトゥンドレノンの構造的および遺伝的特徴を明らかにする.
生物合成経路とチューンドレノンの生成の調節を調査する.

主な方法:

メチロバクター・トゥンドリパルドゥムの生物情報解析
ツンドレノンの構造の解明
トンドレノンの生物合成遺伝子群との遺伝的関連性
クオラムセンシング分析

主要な成果:

複雑な構造を持つユニークな代謝物であるトゥンドレノンを特定し,特徴づけました.
ツンドレノンは,コリスマート由来の断片と改変された脂質の尾からなる.
トンドレノンと生物合成遺伝子群の遺伝的関連を確立した
定数感知がトンドレノンの生成を制御することを示した.

結論:

メタンを酸化するバクテリアは,新しい天然製品を生み出す可能性のある多様な二次代謝を備えています.
ツンドレノンは新しい分子構造でバイオテクノロジーの応用が可能です
メタンを酸化するバクテリアのさらなる探索は,新しい化合物や経路を発見するために正当化されています.

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