ミツバチの巣の迷路は,海馬に依存する空間ナビゲーションを研究するための新しいテストを提供します
Ruth A Wood1, Marius Bauza1, Julija Krupic2,3
1Sainsbury Wellcome Centre, UCL, London W1T 4JG, UK.
Nature
|January 25, 2018
まとめ
新しいハネコブの迷路は ネズミの空間ナビゲーションを効果的に研究し 制御された環境でナビゲーション戦略と ヒポカンプスの損傷が学習に与える影響を評価します
科学分野:
- 神経科学
- 動物 の 行動
背景:
- 空間ナビゲーションは生存に不可欠であり,行動パラダイムを使用して広く研究されています.
- モリスの水道迷路のような既存のテストは 動物の選択を制御し 目標方向の知識を評価する上で 限界があります
研究 の 目的:
- ネズミの空間ナビゲーションを研究するための優れた行動パラダイムとしてミツバチの迷路を導入し,検証する.
- この新しい迷路の中で ネズミの空間的学習と意思決定に影響を与える要因を調査します
主な方法:
- ミツバチの巣の迷路には 37の独立制御のプラットフォームがあります
- ネズミは順番に移動し 隣接するプラットフォームを ターゲットプラットフォームの近さに基づいて選択します
- 性能は,プラットフォームの角度,ゴール距離,ゴールヘッディングの方向などの選択要因に基づいて分析されます.
主要な成果:
- ネズミはミツバチの迷路で 素早く学習します
- ナビゲーションの選択は,プラットフォームの角度,ゴール距離,ゴールヘッディングの方向に大きく影響されます.
- ヒッポキャンパスの損傷を受けたネズミは 学習障害と意思決定の障害を示します
結論:
- ミツバチの巣の迷路は従来の方法と比較して 強化された制御と評価能力を提供します
- 詳細な空間ナビゲーション戦略と 神経損傷の影響を分析できます
- このパラダイムは,ナビゲーションタスク中の単細胞記録の可能性を含むさらなる研究を促進します.
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