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Updated: Feb 15, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
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Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

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進化的に保存された遺伝子族は,陽子選択性イオンチャネルをコードする

Yu-Hsiang Tu1, Alexander J Cooper1, Bochuan Teng1

  • 1Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA.

Science (New York, N.Y.)
|January 27, 2018
PubMed
まとめ

研究者らは,オトペトリン1 (OTOP1) がマウスの味覚細胞で陽子選択イオンチャネルを形成することを発見した. この発見は 細胞の電気信号と 陽子チャネル機能の理解を 広げています

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
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Protein Families02:47

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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