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関連する概念動画

Functional Classification of Joints01:09

Functional Classification of Joints

7.1K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
7.1K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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長い非コーディングRNAの機能的分類と実験的解剖

Florian Kopp1, Joshua T Mendell2

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|January 27, 2018
PubMed
まとめ

研究者は,ゲノムに豊富に存在する長いノンコーディングRNA (lncRNA) の機能を理解するための新しい方法を開発しています. この研究は,遺伝子調節と疾患のより良い洞察を得るために,lncRNAの活動を分類することを目的としています.

キーワード:
lncRNA について非コーディングRNA

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Isolation of Small Noncoding RNAs from Human Serum
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関連する実験動画

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科学分野:

  • ゲノミクス
  • 分子生物学
  • トランスクリプトミクス

背景:

  • ゲノムは広範囲に転写され,多数の長いノンコーディングRNA (lncRNA) を生成する.
  • 増強剤やプロモーターのような DNA 調節要素は双方向転写を開始する.
  • 機能的な lncRNA を広大なトランスクリプトームから区別することは大きな課題です.

研究 の 目的:

  • lncRNAの機能を分類し解明するための概念的および実験的枠組みを提供すること.
  • lncRNAロキーを,その調節メカニズム (cis vs. trans) に基づいて分類する.
  • lncRNAの活性を解析するための実験的戦略を提案する.

主な方法:

  • 現在の lncRNA 研究と方法論のレビュー
  • lncRNAロシの分類は,シス作用およびトランス作用である.
  • lncRNA機能を分析するための実験的アプローチの提案.

主要な成果:

  • 作用形態 (cis または trans) に基づいて lncRNAロキーを分類するための枠組み.
  • lncRNAの役割を調査するための実験戦略を提案した.
  • 新しい生物学的な洞察を明らかにするために これらの戦略の可能性を強調します

結論:

  • lncRNAの機能を理解することは,生理学と病気の知識の進歩に不可欠です.
  • 提案された枠組みは,lncRNA研究に対する体系的なアプローチを提供します.
  • lncRNAの生物学に関するさらなる調査は 重要な発見を約束しています