ディヴェルゴリドIの選択的合成
Daniel W Terwilliger1, Dirk Trauner1,2
1Department of Chemistry, Ludwig-Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany.
Journal of the American Chemical Society
|January 30, 2018
まとめ
研究者は強力な抗菌剤であるダイバーゴリドIを合成しました この研究は,その構造を確認し,その複雑なリングシステムのための選択的生物模倣サイクリング経路を示しています.
科学分野:
- 有機化学
- 薬剤化学
- 自然製品 化学
背景:
- ディヴェルゴリドIはナフトキノンのアンサミシンで,広範囲の抗菌作用があります.
- その複雑な四環構造は,環の収縮によってマクロサイクルの前駆体から発生することが提案されています.
研究 の 目的:
- ダイバーゴリドIの収束性およびエナチオ選択性合成を達成する.
- ダイバーゴリドIの絶対的および相対的構成を決定する.
- 提案された生物模倣サイクリング経路の選択性を調査する.
主な方法:
- コンバージェント・シンセス戦略
- エナチオセレクティブ合成技術
- 構造の解明 (NMR,MS,X線結晶 - 暗示)
- 生物模倣サイクリング研究
主要な成果:
- ダイバーゴリドIの 合成が成功しました
- ダイバーゴライドIの絶対的および相対的立体化学の確認
- プロト・ディヴェルゴリドの前駆体のバイオミメティックサイクリングにおける高い選択性の実証.
結論:
- ダイバーゴライドIの 実践的で効率的な合成経路が開発されました
- 合成は,リングの収縮を含む提案された生物合成経路を検証する.
- この研究は,天然製品の合成における選択的バイオミメティック変換の可能性を強調しています.
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