関連する実験動画

Updated: Feb 15, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

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PCSK9·LDLR相互作用の小分子阻害剤

Jaru Taechalertpaisarn1, Bosheng Zhao1, Xiaowen Liang2

  • 1Department of Chemistry , Texas A & M University , Box 30012, College Station , Texas 77842 , United States.

Journal of the American Chemical Society
|January 31, 2018
PubMed
まとめ

研究者らは,心臓病の重要な経路であるPCSK9-LDLR相互作用を標的とした新しい小分子を発見しました. これらの化合物は この重要なタンパク質結合を 破壊することで 新しい治療法の開発の可能性を示しています

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK908:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

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