身体活動における6年間の変化と心不全のリスク: ARIC研究
Roberta Florido1,2, Lucia Kwak2, Mariana Lazo3
1Department of Medicine, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease (R.F., G.G., R.S.B., C.E.N.).
Circulation
|February 2, 2018
まとめ
中年でも身体活動 (PA) を増やすことは,心不全 (HF) のリスクを有意に低下させます. 推奨されるPAを維持することは最大の利点ですが,活動を開始または増やすこともHFの発生率を減少させます.
科学分野:
- 心臓病科
- 予防医学
- 公衆衛生
背景:
- より高い身体活動 (PA) は,心不全 (HF) のリスクの減少と関連しています.
- PAレベルの変化がHFリスクに与える影響は不明である.
研究 の 目的:
- 6年間の身体活動の変化と心不全のリスクとの関連を調査する.
- 心不全の発生に 影響するかどうかを判断するためです
主な方法:
- Atherosclerosis Risk in Communities (ARIC) の11,351人の参加者を分析した.
- 身体活動はアンケートで評価され,カテゴリ化 (推奨,中等,劣等) された.
- コックス回帰モデルで19年間にわたるPAとその後のHFリスクの変化を分析した.
主要な成果:
- 継続的に推奨されたPAは,最も低いHFリスク (HR,0. 69) と関連していました.
- 低血圧から推奨値まで上昇すると,HFのリスクも著しく低下しました (HR,0. 77).
- 6年間における1SDの血圧上昇は,将来のHFリスクの低下と関連していた (HR,0. 89).
結論:
- 心不全のリスクを減らすには,推奨される運動を維持することが最適です.
- 中年期後半でも 身体活動を開始したり 増強したりすると 心不全のリスクが低くなります
- 心不全の予防には,身体活動を増やす戦略が不可欠です.
関連する概念動画
01:29Heart Failure II: Pathophysiology
1.0K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
01:17Pathophysiology of Heart Failure
4.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
01:27Heart Failure I: Introduction
966
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
966
01:22Heart Failure VI: Adjunct Therapies
402
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
402
01:22Heart Failure Drugs: Diuretics
1.0K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.0K
01:30Heart Failure V: Medical Management
369
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
369