関連する実験動画

Updated: Feb 15, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

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MDA5媒介の炎症の原因となるのは,アルウ・デュプレックスRNAに対する自己耐性障害である

Sadeem Ahmad1, Xin Mu1, Fei Yang1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Cell
|February 4, 2018
PubMed
まとめ

MDA5受容体の異常な活性化により,Aluレトロエレメントからの細胞 dsRNAによるアイカルディ・グティエール症候群 (AGS) のような免疫障害が発生する. MDA5のAGS変種は,これらの自己dsRNAを認識し,免疫系の調節障害を引き起こします.

キーワード:
エイカルディ・グティエール症候群アルーIFIH1 についてMDA5 について自発性炎症生まれつきの免疫レトロエレメント

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